Antifungal pharmacodynamics: Latin America's perspective
نویسندگان
چکیده
منابع مشابه
Antifungal pharmacokinetics and pharmacodynamics.
Successful treatment of infectious diseases requires choice of the most suitable antimicrobial agent, comprising consideration of drug pharmacokinetics (PK), including penetration into infection site, pathogen susceptibility, optimal route of drug administration, drug dose, frequency of administration, duration of therapy, and drug toxicity. Antimicrobial pharmacokinetic/pharmacodynamic (PK/PD)...
متن کاملPharmacokinetics and pharmacodynamics in the development of antifungal compounds.
Antimicrobial pharmacodynamics describe the relationship between drug exposure and treatment outcome. Pharmacodynamic studies provide information useful for dose level and dosing interval selection and for the development of in vitro susceptibility guidelines. Pharmacodynamic observations from animal model studies have proven useful for outcome predictions in the treatment of human infections. ...
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Antifungal susceptibilities (NCCLS, approved standard M27-A, 1997) were determined for the reference strain ATCC 90028 and 21 clinical isolates of Candida albicans with varying levels of fluconazole susceptibility using RPMI 1640 (RPMI) and 80% fresh human serum-20% RPMI (serum). Sixty-four percent (14 of 22) of the isolates tested demonstrated significant decreases (> or = 4-fold) in fluconazo...
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Pharmacodynamic studies examine the relationship between drug pharmacokinetics and outcome. These investigations have been shown to be helpful for the design of dosing intervals, choice of optimal dose levels, and the development of susceptibility breakpoints. Pharmacodynamic studies with available antifungal agents have been useful in developing optimal dosing regimens to improve efficacy and ...
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The historical processes involved in Chagas disease transmission relate to the patterns and conditions of human settlements, especially in rural areas, due to proximity to forest areas, where both vectors and Trypanosoma cruzi can occur, combined with precarious housing conditions and underlying poverty. However, seasonal and permanent rural-urban migration has played a major role in re-mobiliz...
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ژورنال
عنوان ژورنال: The Brazilian Journal of Infectious Diseases
سال: 2017
ISSN: 1413-8670
DOI: 10.1016/j.bjid.2016.09.009